:root{
  --bg:#0f1115; --panel:#171a21; --panel2:#1e222b; --line:#2a2f3a;
  --text:#e6e9ef; --muted:#8b93a3; --accent:#4ea1ff; --accent2:#2d6fb8;
  --cds:#3fb56b; --utr5:#e0a13a; --utr3:#c97b2c; --intron:#6b7280;
  --promoter:#a96bd6; --downstream:#7c8aa0; --exon:#5aa0c9; --intergenic:#444b58;
}
*{box-sizing:border-box}
body{margin:0;font-family:-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif;
  background:var(--bg);color:var(--text);font-size:14px}
header{display:flex;align-items:baseline;gap:18px;padding:14px 22px;border-bottom:1px solid var(--line);
  background:var(--panel)}
h1{font-size:18px;margin:0;font-weight:600}
h1 .sub{font-size:12px;color:var(--muted);font-weight:400;margin-left:6px}
.status{margin-left:auto;font-size:12px;color:var(--muted)}
.status .ok{color:var(--cds)} .status .bad{color:#e2645a}

.tabs{display:flex;gap:2px;padding:0 18px;background:var(--panel);border-bottom:1px solid var(--line)}
.tab{background:none;border:none;color:var(--muted);padding:10px 16px;cursor:pointer;
  border-bottom:2px solid transparent;font-size:13px}
.tab:hover{color:var(--text)}
.tab.active{color:var(--text);border-bottom-color:var(--accent)}
.tabpane{display:none;padding:18px 22px}
.tabpane.active{display:block}

.searchbar{display:flex;gap:10px;align-items:center;flex-wrap:wrap;margin-bottom:14px}
.searchbar input[type=text]{flex:1;min-width:280px;padding:9px 12px;background:var(--panel2);
  border:1px solid var(--line);border-radius:7px;color:var(--text);font-size:14px}
.searchbar input[type=number]{width:90px;padding:7px;background:var(--panel2);
  border:1px solid var(--line);border-radius:6px;color:var(--text)}
.searchbar button,#geneSearchBtn{padding:9px 18px;background:var(--accent2);border:none;
  border-radius:7px;color:#fff;cursor:pointer;font-size:14px}
.searchbar button:hover{background:var(--accent)}
.searchbar button.secondary{background:var(--panel2);border:1px solid var(--line);color:var(--text)}
.searchbar button.secondary:hover{border-color:var(--accent);background:var(--panel2)}
.searchbar button:disabled{opacity:.45;cursor:not-allowed}
.searchbar button:disabled:hover{background:var(--panel2);border-color:var(--line)}
.flank{font-size:12px;color:var(--muted);display:flex;align-items:center;gap:6px}
select{padding:7px 9px;background:var(--panel2);border:1px solid var(--line);border-radius:6px;color:var(--text)}

.results{display:flex;flex-direction:column;gap:6px;margin-bottom:14px}
.gene-hit{padding:10px 12px;background:var(--panel);border:1px solid var(--line);border-radius:7px;
  cursor:pointer;display:flex;gap:10px 14px;align-items:center;flex-wrap:wrap}
.gene-hit:hover{border-color:var(--accent)}
.gene-hit .gid{font-weight:600}
.gene-hit .loc{color:var(--muted);font-size:12px}
.gene-hit .defline{flex-basis:100%;color:var(--muted);font-size:12px;font-style:italic}
.sym{display:inline-block;padding:1px 8px;border-radius:10px;font-size:12px;font-weight:600;
  background:rgba(78,161,255,.15);color:var(--accent);border:1px solid var(--accent2)}

.hidden{display:none!important}
.genehead{display:flex;align-items:baseline;gap:16px;margin-bottom:8px;flex-wrap:wrap}
#geneTitle{margin:0;font-size:17px}
#geneTitle .sym{vertical-align:middle;margin-left:8px}
.genefunc{flex-basis:100%;color:var(--text);font-size:12.5px;font-style:italic;opacity:.9}
.genemeta{color:var(--muted);font-size:12px}
.warning{background:#3a2f1a;border:1px solid #6b5320;color:#e7c98a;padding:8px 12px;
  border-radius:6px;margin:8px 0;font-size:12px}

.counts{display:flex;flex-wrap:wrap;gap:8px;margin:12px 0}
.countchip{display:flex;align-items:center;gap:7px;background:var(--panel);border:1px solid var(--line);
  border-radius:20px;padding:5px 12px;font-size:12px}
.countchip .dot{width:10px;height:10px;border-radius:50%}
.countchip b{font-size:13px}

.track-wrap{background:var(--panel);border:1px solid var(--line);border-radius:8px;padding:10px;
  margin-bottom:16px;overflow-x:auto}
#geneTrack svg{display:block}
.lolli{cursor:pointer}
.lolli:hover circle{stroke:#fff;stroke-width:1.5}

.snptable-wrap{overflow-x:auto;border:1px solid var(--line);border-radius:8px}
.snptable{border-collapse:collapse;width:100%;font-size:13px}
.snptable th{position:sticky;top:0;background:var(--panel2);text-align:left;padding:8px 10px;
  border-bottom:1px solid var(--line);cursor:pointer;user-select:none;white-space:nowrap}
.snptable th:hover{color:var(--accent)}
.snptable td{padding:7px 10px;border-bottom:1px solid var(--line)}
.snptable tbody tr{cursor:pointer}
.snptable tbody tr:hover{background:var(--panel)}
.rpill{display:inline-block;padding:2px 9px;border-radius:11px;font-size:11px;color:#0c0e12;font-weight:600}

.muted{color:var(--muted);font-size:12px;margin:6px 0}
.help{max-width:760px;line-height:1.65}
.help h2{font-size:15px;margin-top:22px}
.help code{background:var(--panel2);padding:1px 6px;border-radius:4px}
.help li{margin:4px 0}

.modal{position:fixed;inset:0;background:rgba(0,0,0,.6);display:flex;align-items:center;justify-content:center;z-index:50}
.modal-box{background:var(--panel);border:1px solid var(--line);border-radius:10px;max-width:680px;
  width:92%;max-height:86vh;overflow:auto;padding:22px;position:relative}
.modal-close{position:absolute;top:10px;right:14px;background:none;border:none;color:var(--muted);
  font-size:26px;cursor:pointer;line-height:1}
.modal-close:hover{color:var(--text)}
.kv{display:grid;grid-template-columns:130px 1fr;gap:4px 12px;margin:10px 0;font-size:13px}
.kv .k{color:var(--muted)}
.gtbars{margin:14px 0}
.gtbar{display:flex;align-items:center;gap:8px;margin:3px 0;font-size:12px}
.gtbar .lab{width:120px;color:var(--muted)}
.gtbar .bar{height:14px;border-radius:3px;background:var(--accent2)}
.grouptbl{width:100%;border-collapse:collapse;font-size:12px;margin-top:6px}
.grouptbl th,.grouptbl td{padding:5px 8px;border-bottom:1px solid var(--line);text-align:left}
.spin{color:var(--muted);padding:14px}

/* genes overlapping a region (Region browser) */
.reg-genes{margin:4px 0 14px}
.reg-genes-head{font-size:13px;margin-bottom:8px;color:var(--text)}
.reg-genes-list{display:flex;flex-wrap:wrap;gap:7px}
.gene-chip{display:inline-flex;align-items:center;gap:6px;padding:4px 10px;font-size:12px;
  background:var(--panel);border:1px solid var(--line);border-radius:14px;cursor:pointer}
.gene-chip:hover{border-color:var(--accent);background:var(--panel2)}
.gene-chip .gid{font-weight:600}
.gene-chip .muted{margin:0}

/* NCBI-style gene track (Region browser) */
.region-track{margin:6px 0 12px;overflow-x:auto;border:1px solid var(--line);border-radius:8px;
  background:var(--panel);padding:8px}
.regtrack-svg{display:block}
.rt-gene{cursor:pointer}
.rt-gene polygon{transition:fill .1s}
.rt-gene:hover polygon{fill:var(--accent)}
.rt-gene .rt-lab{pointer-events:none}
.snpbar{display:flex;align-items:center;gap:12px;margin:8px 0;flex-wrap:wrap}
.snpbar button{padding:7px 14px;background:var(--panel2);border:1px solid var(--line);border-radius:7px;
  color:var(--text);cursor:pointer;font-size:13px}
.snpbar button:hover{border-color:var(--accent)}
.snpbar button:disabled{opacity:.5;cursor:default}

/* maps (Leaflet) */
.bigmap{height:540px;border:1px solid var(--line);border-radius:8px;margin:6px 0;background:var(--panel2)}
.snpmap{height:330px;border:1px solid var(--line);border-radius:8px;margin:2px 0 4px;background:var(--panel2)}
.maplegend{display:flex;flex-wrap:wrap;gap:14px;margin:8px 0;font-size:12px;color:var(--muted)}
.maplegend .lgi{display:inline-flex;align-items:center;gap:6px}
.maplegend .dot{width:11px;height:11px;border-radius:50%;display:inline-block;border:.5px solid #1a1a1a}
.leaflet-popup-content{font-size:12px;line-height:1.45}

/* per-gene genotype-table download button */
.genebtn{margin-top:10px;padding:7px 14px;background:var(--panel2);border:1px solid var(--line);
  border-radius:7px;color:var(--text);cursor:pointer;font-size:13px}
.genebtn:hover{border-color:var(--accent)}

/* genotype-category pie tables (SNP popup) */
.snp-group-pies{margin:14px 0}
.pielegend{font-size:12px;color:var(--muted);display:flex;gap:14px;flex-wrap:wrap;align-items:center;margin:6px 0 2px}
.pielegend .sw{display:inline-block;width:11px;height:11px;border-radius:2px;margin-right:4px;vertical-align:-1px}
.gtinsight{font-size:12.5px;color:var(--text);margin:2px 0 4px;display:flex;align-items:center;gap:8px;flex-wrap:wrap;line-height:1.5}
.gtinsight .dot{width:7px;height:7px;border-radius:50%;background:var(--accent);display:inline-block;flex:none}
.gtmcap{font-size:11px;color:var(--muted);margin:6px 0 4px}
.gtmatrix{border-collapse:collapse;margin:4px 0}
.gtmatrix th{font-weight:600;font-size:12px;color:var(--text);padding:4px 8px;text-align:center}
.gtmatrix th.rowlab{text-align:right}
.gtmatrix th.margh,.gtmatrix tr.totrow th.rowlab{color:var(--muted)}
.gtmatrix td{width:76px;height:76px;text-align:center;vertical-align:middle;border:1px solid var(--line);padding:2px}
.gtmatrix .gpie{display:flex;justify-content:center;align-items:center;transition:transform .12s ease}
.gtmatrix td:hover .gpie{transform:scale(1.14)}
.gtmatrix .cn{font-size:10px;color:var(--muted);line-height:1;margin-top:1px}
.gtmatrix td .z{color:var(--muted);opacity:.3}
.gtmatrix td.marg{background:rgba(255,255,255,.035)}
.gtmatrix td.corner{background:rgba(78,161,255,.12)}
.gtmatrix tr:hover td{background:rgba(255,255,255,.05)}
.gtmatrix tr:hover td.corner{background:rgba(78,161,255,.16)}
.gtmatrix tr.totrow td{border-top:2px solid var(--accent2)}